Cancer Peptide Vaccine

Peptide vaccine therapy is an immunotherapy that aims to activate cytotoxic T lymphocytes (CTL) (*1) in patients by inoculating antigen peptides. Cancer cells present antigen peptides (which act as marks of cancer) as complexes with HLA molecules (*2) on their surfaces. Once educated by a peptide vaccine to recognize a certain mark of cancer, CTLs will proliferate to find and kill relevant cancer cells.

Cytotoxic activity of CTLs against cancer cells 

Once CTLs recognize tumor antigen peptides, CTLs release cytotoxic granules and induce Fas/Fas ligand interaction, and then cause cancer cell death by DNA fragmentation.

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URLC10 peptide-induced CTLs (colorless)attack and kill URLC10-positive tumor cells(Green). The tumor cells were killed after 5 hours of co-culture with CTLs. ; Time-lapse images captured by fixed pointed camera every 1 minute for 5 hours

(*1) Cytotoxic T lymphocyte (CTL)

Also called killer T cell. It is a lymphocyte that recognizes and kills cancer cells and virus-infected cells.

(*2) HLA molecule

It presents fragments (peptides) of intracellular self and non-self (cancer- or virus-derived) proteins to the cell surface. Various immune responses are caused by T cells recognizing peptides presented by HLA molecules. Polymorphic patterns of HLA genes are different depending on countries and ethnic groups. About six out of ten people in Japan have the HLA-A*24:02 type.

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