TCR Analysis and others

Clinical significance of T cell clonality and expression levels of immune-related genes in endometrial cancer. Ikeda Y,Kiyotani K, PY Yew, Sato S, Imai Y, Yamaguchi R, et al. Oncology Reports. 2017; doi: 10.3892/or.2017.5536.

Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma. Hiroyuki Inoue, Jae-Hyun Park, Kazuma Kiyotani, Makda Zewde, Azusa Miyashita, Masatoshi Jinnin, et al. Oncoimmunology. 2016; 30;5(9):e1204507.

Myasthenic crisis and polymyositis induced by one dose of nivolumab. Kimura T, Fukushima S, Miyashita A, Aoi J, Jinnin M, Kosaka T, et al. Cancer Sci. 2016; 107(7):1055-8.

Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. Park JH, Jang M, Tarhan YE, Katagiri T, Sasa M, Miyoshi Y, et al. Int J Oncol. 2016; 49(2):471-8.

Characterization of the T cell repertoire by deep T cell receptor sequencing in tissues and blood from patients with advanced colorectal cancer. Tamura K, Hazama S, Yamaguchi R, Imoto S, Takenouchi H, Inoue Y, et al. Oncol Lett. 2016; 11(6):3643-3649.

Characterization of T-cell Receptor Repertoire in Inflamed Tissues of Patients with Crohn’s Disease Through Deep Sequencing. Chapman CG, Yamaguchi R, Tamura K, Weidner J, Imoto S, Kwon J, et al. Inflamm Bowel Dis. 2016; 22(6):1275-85.

The importance of immunopharmacogenomics in cancer treatment: Patient Selection and Monitoring for Immune Checkpoint Antibodies. N Choudhury, Y Nakamura. Cancer Science 2016; 107(2):107-15.

Low T-cell Receptor Diversity, High Somatic Mutation Burden, and High Neoantigen Load as Predictors of Clinical Outcome in Muscle-invasive Bladder Cancer. NJ Choudhury, K Kiyotani, KL Yap, A Campanile, T Antic, PY Yew, et al. Eur Urol Focus. 2015; 2405-4569

Immunopharmacogenomics. Y Nakamura. Springer. 2015

Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients. PY Yew, H Alachkar, R Yamaguchi, K Kiyotani, H Fang, KL Yap, HT Liu, et al. Bone Marrow Transplant. 2015; 50(9):1227-34.

Characterization of T Cell Repertoire of Blood, Tumor and Ascites in Ovarian Cancer Patients using Next Generation Sequencing. M Jang, PY Yew, K Hasegawa, Y Ikeda, K Fujiwara, GF Fleming, et al. Oncoimmunology. 2015; 14;4(11): e1030561.

Highly Clonal Regulatory T cell population in Follicular Lymphoma–Inverse Correlation with the diversity of CD8+ T cells. X Liu, G Venkataraman, J Lin, K Kiyotani, S Smith, M Montoya, et al. Oncoimmunology. 2015; 3;4(5):e1002728.

Quantitative T cell repertoire analysis by deep cDNA sequencing of T cell receptor α and β chains using next-generation sequencing (NGS). H Fang, R Yamaguchi, X Liu, Y Daigo, PY Yew, C Tanikawa, K Matsuda, et al. Oncoimmunology.　2014; 3(12):e968467.

Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancerspecific point mutation. M Leisegang, B Engels, K Schreiber, PY Yew, K Kiyotani, C Idel, et al. Clinical Cancer Research. 2015; 2361

Critical roles of non-histone protein lysine methylation in human tumorigenesis. Hamamoto R, Saloura V, Nakamura Y. Nat Rev Cancer. 2015; 15(2):110-24.

A systematic approach to the development of novel therapeutics for lung cancer using genomic analyses. Y Daigo, A Takano, K Teramoto, S Chung, Y Nakamura, Clin Pharmacol Ther. 2013; 94(2):218-23.